- Question from Sprph: How necessary is Cytoxan in the sequential dose-dense regimen?
Cytoxan (chemical name: cyclophosphamide) is one of the oldest drugs known to be effective against breast cancer. It would probably be going too far, however, to say that this will always be considered necessary.
We have trials in women with negative lymph nodes that are attempting to answer this question. Until we have studies saying that it is OK to skip this drug, I would recommend it as standard of care. If there is a reason that you cannot have this drug, your physician will discuss other options with you. Many women read about Cytoxan and are concerned about the risk of long-term effects. At the doses used in treating breast cancer, however, such long-term effects are very rare.
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