DCIS treatment with ER, PR negative?
Meet the Experts
Generosa Grana, M.D., F.A.C.P. is the director of the Cooper Cancer Institute and heads the division of hematology/medical oncology at Cooper University Hospital.
Nicholas Robert, M.D. is a co-chair of the Breast Committee of the U.S. Oncology Research Network and also chairs the Cancer Committee and Research Committee of the Inova Fairfax Hospital's Cancer Center.
Question from LizA: I'd like to know if there are any new research findings on DCIS treatment, especially for the patient with ER, PR negative.
- Answer —Nicholas Robert, M.D.: I'm not aware of any new research regarding the treatment of patients with DCIS where the hormone receptors for estrogen and progesterone are negative. Interestingly, some of these DCIS tumors are positive for HER2, raising the question of whether an anti-HER2 strategy can have any potential benefit, especially now that we have an oral anti-HER2 drug. At this time, the role for such an approach would be speculative but there may be in the future an interest in exploring this approach. The question does raise the role of local management of DCIS regardless of estrogen/progesterone status. There was data showing the benefits of using radiation to reduce the risk of local return in patients who were treated with lumpectomy for their DCIS.
On Wednesday, June 20, 2007, the Ask-the-Expert Online Conference was called Updates from the 2008 ASCO Annual Meeting. Generosa Grana, M.D., F.A.C.P. and moderator Nicholas Robert, M.D. answered your questions about the latest news on breast cancer screening, treatment, and side effects reported at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.
The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.
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