Research on ILC and survival rates?
Meet the Experts
Jennifer Griggs, M.D., M.P.H. is a medical oncologist specializing in the treatment of breast cancer, dedicated to developing programs that improve the well-being of women treated for breast cancer.
Question from Nancy: Has there been any new research on invasive lobular cancer and the chances of long term survival?
- Answer —Jennifer Griggs, M.D., M.P.H.:
Lobular breast cancers, which make up about 5% of invasive breast cancers, can be hard to detect by standard mammography. The cells tend to, instead of grouping together, line up in rows which can make even physical exam of a lobular cancer difficult. Many women describe a "thickening" within the breast, and when the mammogram is negative, the diagnosis can be elusive. In terms of prognosis and chance of cure, lobular cancers appear to be quite similar in terms of risk of recurrence compared to ductal, although some large studies have suggested a slightly better prognosis. Although difficult to detect, lobular cancers are generally slower growing and more likely to contain the estrogen receptor which is associated with an improved prognosis. Lobular cancers are also nearly always HER2-negative, which again is associated with an improved prognosis. There is no evidence that hormonal therapy is less effective in lobular cancers. Because the tumors are slower growing and more likely to be ER-positive, the benefit of chemotherapy is smaller than it would be in a faster growing tumor.
On December 19, 2007, our Ask-the-Expert Online Conference was called Updates from San Antonio 2007. Jennifer Griggs, M.D., M.P.H. answered your questions and shared the newest research presented at this year's San Antonio Breast Cancer Symposium.
The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.
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