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Effectiveness of dose-dense chemo?

Page last modified on: November 20, 2008
Question from DeborahL: Is there any news about the effectiveness of dose-dense chemo?
Answer —Generosa Grana, M.D., F.A.C.P.: There was news presented looking at dose-dense chemotherapy showing that it is still very effective chemotherapy, but that in certain subsets it may not be as effective as we originally had thought. Particularly in the hormone-receptor-positive subsets, the impact is less. In my mind, that doesn't mean we shouldn't use this regimen. I think it's still a very good regimen and the subject of a very important study that's being done across the country right now, so further research will shed light on its true role. But again, it is still a very active regimen.

NSABP B38 is ongoing, comparing dose-dense AC followed by Taxol to a regimen known as TAC. A third arm in that study is the dose-dense regimen with the addition of Gemzar (chemical name: gemcitabine).

On Wednesday, December 21, 2005, our Ask-the-Expert Online Conference was called Updates from San Antonio Breast Cancer Symposium 2005. Generosa Grana, M.D., F.A.C.P. and moderator Marisa Weiss, M.D. brought you the highlights of the 2005 Breast Cancer Symposium and answered your questions about the latest diagnostic and treatment options for breast cancer.

The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Meet the Experts

Generosa Grana, M.D., F.A.C.PGenerosa Grana, M.D., F.A.C.P. is the director of the Cooper Cancer Institute and heads the division of hematology/medical oncology at Cooper University Hospital.

Marisa Weiss, M.D. is a radiation oncologist specializing in breast cancer and the founder, president, and guiding force behind Breastcancer.org.

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