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What feeds receptor-negative breast cancer?

Page last modified on: November 20, 2008
Question from Tahoe Nancy: Any new information about what feeds receptor-negative breast cancer tumors?
Answer —Generosa Grana, M.D., F.A.C.P.: I think there is a lot of interest in studying the cancer that is hormone-receptor-negative to get a better handle on the pathways involved in those tumors. As of yet, we don't have a great understanding of what drives those tumors or what pathways we can block to effectively interfere with those tumors. What we do know about women who have hormone-receptor-negative cancers is that they tend to benefit more from the typical regimens such as dose-dense chemotherapy (AC followed by Taxol given at two week intervals). The woman who is hormone-receptor-negative tends to benefit more. Those women don't benefit from hormonal agents, but again there are some very interesting compounds being developed that may be perfect for those women, such as Avastin [a humanized monoclonal antibody], such as lapatinib, and some of the other compounds in development will target these cancers.

On Wednesday, December 21, 2005, our Ask-the-Expert Online Conference was called Updates from San Antonio Breast Cancer Symposium 2005. Generosa Grana, M.D., F.A.C.P. and moderator Marisa Weiss, M.D. brought you the highlights of the 2005 Breast Cancer Symposium and answered your questions about the latest diagnostic and treatment options for breast cancer.

The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Meet the Experts

Generosa Grana, M.D., F.A.C.PGenerosa Grana, M.D., F.A.C.P. is the director of the Cooper Cancer Institute and heads the division of hematology/medical oncology at Cooper University Hospital.

Marisa Weiss, M.D. is a radiation oncologist specializing in breast cancer and the founder, president, and guiding force behind Breastcancer.org.

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