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Developments in triple-negative treatment?

Page last modified on: November 20, 2008
Question from Roger: What are the latest developments and strategies to treat triple-negative advanced disease?
Answers —Nicholas Robert, M.D.: Triple-negative breast cancer refers to tumors that are negative for estrogen and progesterone as well as negative for the HER2 receptor. This represents about 15% of patients. Fortunately, this group of patients appears to respond better to chemotherapy than women who are estrogen receptor-positive. Also there are now a number of drugs that are available for this group of patients. How best to use these drugs, and maybe others, remains a question. In addition, we know this group of patients is positive for something on a molecular level. There is research being done looking for genes and proteins to better understand the biology of this group of patients. It is expected that in the future we will have targets to shoot for like we have in other breast tumor groups.
Jennifer Griggs, M.D., M.P.H.: One of the most exciting things in breast oncology is the recognition that just like individuals are different, breast cancers are different. So we're getting smarter in our treatment. A couple years ago, we didn't know or refer too commonly to "triple-negative" tumors. The new categories that we have for breast cancer offer promise for more intelligent treatment.

On Wednesday, June 21, 2006, our Ask-the-Expert Online Conference was called Updates from the 2006 ASCO Annual Meeting. Nicholas Robert, M.D. and moderator Jennifer Griggs, M.D., M.P.H. answered your questions about recent advances in breast cancer treatment, updates on breast cancer genetics, information on diet and risk of recurrence, and more.


The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Meet the Experts

Nicholas Robert, M.D.Nicholas Robert, M.D. is a co-chair of the Breast Committee of the U.S. Oncology Research Network and also chairs the Cancer Committee and Research Committee of the Inova Fairfax Hospital's Cancer Center. 

Jennifer Griggs, M.D., M.P.H.Jennifer Griggs, M.D., M.P.H. is a medical oncologist specializing in the treatment of breast cancer, with a a special interest in cancer survivorship, patient-physician communication, and quality of care for women with breast cancer.

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