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Information on AMG 706?

Page last modified on: November 20, 2008
Question from GGT: I just started a clinical trial in Australia for AMG 706. I have secondaries in my liver. Do you have any info on this drug, and if not, what are the latest treatment options for liver secondaries? I have also investigated SIRT—Selective Internal Radiation Therapy.
Answers —Generosa Grana, M.D., F.A.C.P.: Although not actively familiar with this particular compound, the approach to women whose breast cancer has spread to the liver varies, depending on whether that is the only site of disease, and how many lesions are present in the liver. Or whether there are other sites of involvement, such as lungs and bones. Liver-targeted therapies, such as chemoembolization, or other strategies targeting the liver can be utilized in women that have a small number of lesions (two to four lesions). For other patients, systemic chemotherapy may be more appropriate.
Nicholas Robert, M.D.: Regarding the use of AMG 706, this is an agent that affects blood vessel formation and like the drug Avastin (chemical name: bevacizumab), which is another agent that uses a different mechanism, but may provide a similar benefit. I would encourage patients who are eligible for the study to participate. This is how we learn about better ways to treat breast cancer.

On Wednesday, June 20, 2007, the Ask-the-Expert Online Conference was called Updates from the 2008 ASCO Annual Meeting. Generosa Grana, M.D., F.A.C.P. and moderator Nicholas Robert, M.D. answered your questions about the latest news on breast cancer screening, treatment, and side effects reported at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Meet the Experts

Generosa Grana, M.D., F.A.C.PGenerosa Grana, M.D., F.A.C.P. is the director of the Cooper Cancer Institute and heads the division of hematology/medical oncology at Cooper University Hospital.

Nicholas Robert, M.D.Nicholas Robert, M.D. is a co-chair of the Breast Committee of the U.S. Oncology Research Network and also chairs the Cancer Committee and Research Committee of the Inova Fairfax Hospital's Cancer Center. 

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