Other antidepressants for premenopausal women taking Tamoxifen?

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Question from Jenna: Are there other types of antidepressants (other than SSRIs and SNRIs) that a premenopausal patient can safely take with tamoxifen? Have they been extensively studied for interaction?
Answers - Nicholas Robert, M.D. The drug is Effexor (chemical name: venlafaxine) and it’s been shown to be effective. It is used a lot to reduce hot flashes and it does not have a significant impact on tamoxifen. But Effexor is an antidepressant and can be used at higher doses to treat depression.

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