- Question from Deirdre: Is there ongoing research as to exactly what PR+ means to breast cancer? We all know that ER+ means that the lesion is fed by estrogen, but when I look up PR+ it states that the lesion is affected by progesterone but not that it feeds the cancer. Can you explain where the research is on progesterone and breast cancer? Thanks!
- Answers - Nicholas Robert, M.D. The progesterone receptor, we think, is positive when there is an impact on the functioning estrogen receptor. In patients where both receptors are positive, we think that hormonal/endocrine therapy will be more effective. There is an uncommon subset of tumors where the estrogen receptor is negative and the progesterone receptor is positive. We think in that group there are still some benefits to using hormonal treatments, although the benefit is less.
The Ask-the-Expert Online Conference called Updates From the 2009 ASCO Annual Meeting featured Nick Robert, M.D. and Beth Baughman Dupree, M.D., F.A.C.S. answering your questions about the newest findings on risk, screening, treatment, and more.
Editor's Note: This conference took place in June 2009.
The materials presented in these conferences do not necessarily reflect the views of Breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.
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