- Question from LBoch: I had stage I breast cancer and was diagnosed with osteopenia. I am currently on Femara and alendronate and have maintained my bone density. I wanted to know if there are new recommendations to switch patients to zoledronic acid in light of recent studies.
- Answers - Andrew D. Seidman, M.D. Alendronate (brand name: Fosamax) and zoledronate (brand name: Zometa) are both bisphosphonates that can prevent loss of bone density in women receiving aromatase inhibitors such as Femara. Zometa has been most rigorously studied for this benefit in clinical trials known as Z-Fast and Zo-Fast. Alendronate is an oral agent and Zometa is an intravenous drug. There are provocative data that suggest that Zometa may possibly also have a direct anti-tumor effect against breast cancer. We still await other confirmatory studies, however, before we can comfortably tell patients that the use of this class of drugs will prevent the recurrence of breast cancer when used in the adjuvant setting.
The Ask-the-Expert Online Conference called Updates From the 2010 ASCO Annual Meeting featured Andrew Seidman, M.D. and Beth Baughman DuPree, M.D., F.A.C.S. answering your questions about the latest updates on breast cancer risk, screening techniques, treatment options, and more.
Editor's Note: This conference took place in June 2010.
The materials presented in these conferences do not necessarily reflect the views of Breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.
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