What is the data on the effectiveness of ACT versus CT chemotherapy?


Question from KayD: What evidence is there in the effectiveness of ACT versus CT for chemo treatment? Dr. Slamon's thoughts on shelving anthracyclines prompts this question.
Answers - Andrew D. Seidman, M.D. We have one randomized clinical trial involving 1,000 patients that compared the use of AC (Adriamycin [chemical name: doxorubicin], Cytoxan [chemical name: cyclophosphamide]) to TC (Taxotere [chemical name: docetaxel], Cytoxan). (Jones SE. Phase III Trial Comparing Doxorubicin Plus Cyclophosphamide With Docetaxel Plus Cyclophosphamide As Adjuvant Therapy for Operable Breast Cancer. Journal of Clinical Oncology, Vol 24, No 34 (December 1), 2006: pp. 5381-5387.) This trial showed a modest benefit in disease-free survival and overall survival for TC over AC. The question posed asks for comparison of ACT versus TC. On that score, we currently lack any data. While there is a movement toward trying to make Adriamycin and other anthracyclines extinct, I, and I believe a majority of my colleagues, feel strongly that this is misguided. While anthracyclines can damage the heart, their judicious use by capable clinicians results in a very favorable risk/benefit ratio. Anthracyclines remain one of the most effective classes of chemotherapy drugs against breast cancer.

On Thursday, June 10, 2010, our Ask-the-Expert Online Conference was called Updates from the 2010 ASCO Annual Meeting. Andrew Seidman, M.D. and Beth Baughman DuPree, M.D., F.A.C.S. answered your questions about the latest updates on breast cancer risk, screening techniques, treatment options, and more.

The materials presented in these conferences do not necessarily reflect the views of Breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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