Effectiveness of metronomic chemotherapy on metastatic breast cancer?

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Question from RebeccaJ-2: Were there any updates on the effectiveness of metronomic chemotherapy on metastatic breast cancer, both with and without bevacizumab? Thanks.
Answers - Kathy D. Miller, M.D. Metronomic therapy is an approach that uses much lower doses of chemotherapy administered more frequently as a way of inhibiting the growth of blood vessels that may help the tumor grow. This has been most commonly studied using chemotherapy medicines called Cytoxan (chemical name: cyclophosphamide) and methotrexate (brand names: Amethopterin, Mexate, Folex). Those drugs are often given in higher doses as an IV infusion, but they can also be given in lower doses in pill form that would allow women to take the therapy more frequently. In previous studies, that combination has been effective in some women with metastatic disease and was more likely to be effective when combined with Avastin. But I didn't see any new studies of this approach reported at this year's meeting.

The Ask-the-Expert Online Conference called Updates From the 2009 San Antonio Breast Cancer Symposium featured Kathy Miller, M.D. and Kristin Brill, M.D., F.A.C.S. answering your questions about the latest updates on breast cancer risk, screening techniques, treatment options, and more.

Editor's Note: This conference took place in December 2009.

The materials presented in these conferences do not necessarily reflect the views of Breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Copyright 2010. All rights reserved.

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