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July 2008: Triple-Negative Breast Cancer

Last modified on August 20, 2008

Question from KoKo: My mom was recently diagnosed with triple-negative breast cancer. She is Stage I with no lymph node involvement. She underwent six chemo treatments and the 5-day MammoSite radiation. Everyone seems to feel that her prognosis is so grim due to the triple-negative. What can she do now to protect herself? Answers &mdash…

Medications for triple-negative coming?

Last modified on October 13, 2008

Question from Patty: I am not on any of the medications you are talking about as I am triple-negative. Are there any other meds for us coming out in the near future? I have chemo-induced menopause. I was diagnosed in Dec 03, I am almost 4 years out and doing great. Answers — Patricia Ganz, M.D.: In general, we do not add additional therapy…

Prophylactic surgery for triple-negative?

Last modified on October 13, 2008

Question from Joanne: I am BRCA1 positive, and being treated for triple negative breast cancer. I am considering bilateral mastectomy and oophorectomy, but what if a treatment for triple negatives is found? Will I have gone through a lot of surgery/disfigurement for nothing? Answers — Ruth Oratz, M.D., F.A.C.P.: There are many issues…

IBC triple negative treatment?

Last modified on October 13, 2008

Question from JB: What's the most current thinking on treating triple-negative IBC? Also, early trial results on Tykerb indicate positive results for IBCers. How does that translate to triple-negative IBCers? Answer — Gabriel Hortobagyi, M.D., F.A.C.P.: Probably about 40% of inflammatory breast cancers are likely to be triple negative. Those…

Treatments for triple-negatives?

Last modified on October 10, 2008

Question from Photot: What, if anything, is available for those of us who are "triple negative"? Is there anything on the horizon for these types of cancers? Answers — Andrew Seidman, M.D.: I think that is an excellent question and it begs clarification for those who are reading who might not be familiar with the term " ." This refers…

Updates on ER/PR/HER2-negative cancer?

Last modified on February 19, 2009

, PR, or HER2/neu as biologic targets. Therefore, we cannot use hormonal therapy or Herceptin in treating this form of breast cancer. At the present time the standard therapy for triple negative breast cancer is chemotherapy. However, there is a great deal of research on this particular subset of breast cancer to identify other biologic targets…

When was triple-negative identified?

Last modified on August 19, 2008

Question from Skippy123: When did the cancer community begin to identify triple-negatives? How long have we been tracking triple-negative survivors? Answers — George Sledge, M.D.: When we say triple-negative, we mean estrogen-receptor negative, progesterone-receptor negative, and HER2 negative. Routine HER2 testing did not become possible…

Updates on treatment for triple-negative?

Last modified on November 20, 2008

Question from Twink: I was diagnosed in January with triple-negative breast cancer. I don't often read promising news regarding treatment of this type of cancer and would like to hear whether there's anything hopeful on the horizon for us triple-negative types. Also, I did read that carboplatin/cisplatin seems to show better survival results…

Clinical trials for triple-negative?

Last modified on August 18, 2008

Question from Padma Tadi Uppala: I am a breast cancer researcher. My patient has been diagnosed with Stage IV triple-negative breast cancer. She has open sores on the right side of her body including the stomach. She is currently undergoing chemotherapy -- Taxol and Xeloda. What kind of clinical trials (that seem to work) are available for triple…

Genetic testing for triple-negative?

Last modified on August 01, 2008

Question from Maija: So if triple-negative breast cancer is related to a defect in BRCA1, should members of the family be tested when the mother has triple-negative breast cancer? Answer — Larry Norton, M.D.: It is a clue that BRCA1 may be involved. There is no substitute for expert genetic counseling if there is any suspicion of familial…