Best chemo combination for triple-negative?

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Question from Jason222: What is the best chemo combination for the triple-negative?
Answers - George Sledge, M.D. Let me answer in general terms. When we have looked at chemotherapy regimens over the past 2 decades in the adjuvant setting or early disease setting, what we have learned is the addition of taxanes such as Taxol (chemical name: paclitaxel) or Taxotere (chemical name: docetaxel) to previous regimens has added benefit. We also have evidence to suggest that using these regimens in what is called a dose-dense fashion, i.e., more frequent administration of the agents, seems to improve benefit. This appears to be true in triple-negative breast cancers as it is in other subtypes, but perhaps more so in triple-negative breast cancers. We are still wrestling with whether specific drugs should be included or excluded for triple-negative breast cancers. For instance, oncologists are currently arguing over the role of Adriamycin (chemical name: doxorubicin) in early stage breast cancer. Over the next few years we are likely to see a number of new agents enter the adjuvant setting. Currently, for instance, Avastin (chemical name: bevacizumab; an agent that targets blood vessels) is being studied in large adjuvant trials for early stage breast cancer including triple-negative breast cancer. There are also robust studies going on to see whether platinum-based chemotherapies, which damage DNA, may work better in triple-negative breast cancers than they do in other cancer types, but we do not yet have an answer to this question for early stage breast cancer patients.

The Ask-the-Expert Online Conference called Triple-Negative Breast Cancer featured George Sledge, M.D. and Beth Baughman DuPree, M.D., F.A.C.S. answering your questions about triple-negative breast cancer and its treatment.

Editor's Note: This conference took place in July 2008.

The materials presented in these conferences do not necessarily reflect the views of A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Copyright 2010. All rights reserved.

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