The U.S. Preventive Services Task Force is a group of experts that makes recommendations to the U.S. Department of Health and Human Services on policies to prevent diseases, including the best ways to use screening tests such as mammography to meet the health needs of the United States. The task force reviewed several studies and recommended dramatic changes to current breast cancer screening guidelines.
Based on its analysis, the the task force concluded:
These conclusions are based on research that looks at the effect of breast cancer screening on society from a public health perspective. This means the researchers were looking at how changing breast cancer screening guidelines would affect the overall public, rather than individual women. The researchers looked at the medical records of tens of thousands of women screened for and diagnosed with and treated for breast cancer in the past. Using a computer model that took into account the medical data and assumptions about breast cancer diagnosis and treatment, they determined the benefits and risks of changing breast cancer screening guidelines.
The task force said that mammograms done on women age 39 to 69 DO save lives. Still, when the experts compared the number of lives saved by mammograms done in women younger than 50 to the cost of those mammograms (and the problems associated with false positives) they decided that the cost wasn't justified. A false positive is an suspicious area that looks like a cancer but turns out to be normal. Besides the fear of a breast cancer diagnosis, a false positive usually means more costly tests (including biopsies) and follow-up doctor visits. The process can be very stressful and upsetting. The studies analyzed by the task force showed that false positives are more common in younger women. The task force also said that the studies showed no evidence that breast self-exams saved lives, from a public health viewpoint.
While some doctors are concerned about the radiation exposure that women receive during annual screening mammograms, the task force experts didn't think that was a problem and radiation exposure wasn't a reason for suggesting changes to breast cancer screening recommendations.
Breastcancer.org doesn't agree with the recommended changes to breast cancer screening policies proposed by the task force. We feel that that model the task force used to develop the recommended changes isn't accurate and the conclusions are flawed:
The task force estimated that 3% more women would die from breast cancer if the recommended changes were adopted. Expressed as nameless, faceless numbers, this 3% decrease in breast cancer survival might seem like an acceptable trade-off when compared to the economic benefits of changing breast cancer screening policies. But breast cancer affects a very large number of women, so 3% of that number is not insignificant. The reality is that more women -- mothers, daughters, sisters, grandmothers, and aunts -- will die each year from breast cancer, which is neither reasonable nor acceptable.
You may be confused about this news and what it means for you. Breastcancer.org suggests the following:
You also might be interested in reading a note Dr. Marisa Weiss, Breastcancer.org's president and founder, wrote to our community, addressing the task force recommendations. Read Dr. Weiss' note.
Women younger than 50 do not need routine screening mammography for breast cancer, according to new government recommendations, which constitute a departure from other clinical guidelines for breast cancer prevention.
And women ages 50 to 74 need a screening mammogram only every two years, according to the new U.S. Preventive Services Task Force recommendation statement.
Women at high risk for breast cancer should talk to their physicians about the most appropriate screening schedule, the writing committee reported in the Nov. 17 issue of Annals of Internal Medicine.
The task force found insufficient evidence to assess the benefits and harms of screening mammography in women ages 75 and older and the benefits and potential harms of clinical breast examination beyond screening mammography.
The task force's 2002 statement recommended screening mammography every one to two years for all women ages 40 and older, consistent with the American Cancer Society (ACS) recommendation. The ACS has seen no evidence to warrant a change in that recommendation, Len Lichtenfeld, MD, deputy chief medical officer, said in an interview.
"Given the fact that we've seen a significant and continuing decline in breast cancer deaths in both women who are in the 40 to 49 age group and in the 50 and above group, we believe that annual screening beginning at age 40 is consistent with what we consider appropriate medical practice," said Lichtenfeld.
The differences in the task force and ACS recommendations represent "discussions around the edge of the core issue," said George Sledge, MD, a breast cancer specialist at Indiana University in Indianapolis.
"The core issue is that screening mammography reduces breast cancer mortality if it is used on a regular basis," said Sledge, who also is a spokesperson for the American Society of Clinical Oncology. "When you get that really important core issue, the issues that circulate around it ... are largely issues related to balancing risk and benefits or balancing cost and benefit."
"I view this as a significant change, but not something that changes the core message," Sledge added.
The task force based its recommendations on a systematic review of evidence that has come to light since the 2002 recommendation statement. The review included randomized controlled trials that had breast cancer mortality outcomes for screening effectiveness. Various types of studies were used to assess potential harms related to breast cancer screening.
The review showed that:
The findings led the task force to recommend starting mammographic screening at age 50, screening every two years for average-risk women, and that clinicians not teach women how to perform breast self-examination.
The task force also found data insufficient to determine whether clinical breast examination adds anything to mammography, and whether digital mammography and MRI have advantages or disadvantages versus film mammography.
In an accompanying editorial, Karla Kerlikowske, MD, said the recommendations represent a step toward tailored recommendations for preventions based on individual risk. However, she said the scientific basis for such an approach needs bolstering.
"We urgently need risk models with better discriminatory accuracy that can correctly identify persons at all levels of risk," said Kerlikowske, of the San Francisco Veterans Affairs Medical Center. "We also need research to determine the best prevention strategies for levels of risk to maximize prevention benefits while minimizing harms."
Lichtenfeld expressed concern that the different recommendations from the ACS will lead to uncertainty that could adversely affect screening practices.
"The worst message that could go out is that women don't need to be screened or if they feel that there is confusion about the message that they decide not to get screened," said Lichtenfeld. "That would be a terrible outcome of this discussion."
Sledge expressed less concern about the different recommendations and greater concern about women who do not get screened regardless of how the benefits are conveyed to them.
"If you look at even the most conservative recommendations, and I would view the task force recommendations as a very nuanced but very conservative recommendation, you see that perhaps a third of American women never meet those very conservative recommendations," he said. "There are literally millions of women who are not availing themselves or not able to avail themselves of what is a potentially life-saving technology for them."
The task force authors, Kerlikowske, Lichtenfeld, and Sledge reported no relevant disclosures.
Primary source: Annals of Internal Medicine Source reference: U. S. Preventive Services Task Force "Screening for breast cancer: U. S. Preventive Services Task Force recommendation statement" Ann Intern Med 2009; 151: 716-26.Additional source: Annals of Internal MedicineSource reference: Nelson HD, et al "Screening for breast cancer: an update for the U.S. Preventive Services Task Force" Ann Intern Med 2009; 151: 727-37.Additional source: Kerlikowske K "Evidence-based breast cancer prevention: the importance of individual risk" Ann Intern Med 2009; 151: 750-52. Source reference: Kerlikowske K "Evidence-based breast cancer prevention: the importance of individual risk" Ann Intern Med 2009; 151: 750-52.
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