Gene therapy for IBC?


Question from Gina: What kinds of gene therapy are being looked at for IBC?
Answers - Thomas Buchholz I'm not aware of a gene therapy trial.
Gabriel N. Hortobagyi, M.D., F.A.C.P. I'm not aware of a gene therapy trial for inflammatory breast cancer. There are ongoing trials for breast cancer in general, but all of them are in the very early stages of development, mostly Phase 1 trial. But nothing specifically for inflammatory breast cancer. When new drugs are developed, the very first step is to establish what is the best way to give the drug, how much should be given, how frequently, and how well patients tolerate that way of administering the drug. The same is true for gene therapy, for gene therapy is, in a way, a drug. So at this stage in the gene therapy trial, they are trying to determine the best way to administer the gene therapy, how frequently, and how much needs to be administered to get the predicted effect. Only later in the second stage do those clinical trials get to be reliable enough so that one knows that the drug or gene therapy is given the best way so one can expect the best possible results. At this point, gene therapy is not considered part of standard treatment of inflammatory breast cancer.

On Wednesday, October 18, 2006, our Ask-the-Expert Online Conference was called Inflammatory Breast Cancer. Gabriel Hortobagyi, M.D., Thomas Buchholz, M.D., andĀ moderatorĀ Jennifer Sabol, M.D. answered your questions about inflammatory breast cancer, a rare but aggressive form of breast cancer.

The materials presented in these conferences do not necessarily reflect the views of Breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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