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Switch from tamoxifen to aromatase inhibitors?

Page last modified on: August 1, 2008
Question from Randirella: Hello Drs. Norton and Weiss: I was diagnosed with metastatic disease after 9 yrs of dormancy. I just had an oopherectomy. I'd gone back on tamoxifen and now my doc wants me to switch to an aromatase inhibitor. I prefer to stick with tamoxifen, since it’s keeping me stable and I remain asymptomatic. Don't want to use up my tools if I don't have to. Does my logic hold? Thanks for everything you do, I'm a fan.
Answer —Larry Norton, M.D.: I think you should ask your doctor that question, as there may be a reason for using the aromatase inhibitor that you don't know. I agree with your sentiment that you never get off a winning horse. If the medication is working and there are no side effects, then almost always the right thing to do is not switch. However, you really must discuss this with your doctor as there may be facts that are not apparent to you that would necessitate a switch at this time.

On Wednesday, October 17, 2007 our Ask-the-Expert Online Conference was called Living with Metastatic Breast Cancer. Larry Norton, M.D. and moderator Marisa Weiss, M.D. answered your questions about managing day-to-day life with metastatic breast cancer.

The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Larry Norton, M.D.Larry Norton, M.D. is deputy physician-in-chief and director of Breast Cancer Programs at Memorial Sloan-Kettering Cancer Center in New York City.

Marisa Weiss, M.D. is a radiation oncologist specializing in breast cancer and the founder, president, and guiding force behind Breastcancer.org.

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