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Update on PARP inhibitor trial?

Page last modified on: August 1, 2008
Question from Jill: I am BRCA positive and I have heard that the PARP inhibitor (ICEBERG) trials are showing success. Do you have any additional information on the current trial or the upcoming trial at NIH where they will combine the PARP inhibitor with chemo?
Answer —Larry Norton, M.D.: The PARP inhibitors are one of the promising treatments for breast cancer and other cancers, and might make sense for people with the breast cancer that commonly arises in women who have a defect in BRCA1. That type of breast cancer is called triple-negative breast cancer because it is negative for estrogen receptor, progesterone receptor, and HER2. The best way to find out if you are eligible for any of the trials with any PARP inhibitors is to go to www.clinicaltrials.gov or call 1-800-4-CANCER.

On Wednesday, October 17, 2007 our Ask-the-Expert Online Conference was called Living with Metastatic Breast Cancer. Larry Norton, M.D. and moderator Marisa Weiss, M.D. answered your questions about managing day-to-day life with metastatic breast cancer.

The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Meet the Experts

Larry Norton, M.D.Larry Norton, M.D. is deputy physician-in-chief and director of Breast Cancer Programs at Memorial Sloan-Kettering Cancer Center in New York City.

Marisa Weiss, M.D. is a radiation oncologist specializing in breast cancer and the founder, president, and guiding force behind Breastcancer.org.

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