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What's responsible for loss of sex drive?

Page last modified on: September 9, 2009
Question from molly284: I love my husband, but since my lumpectomy, chemo, tamox (and Paxil for the hot flashes) and rads, I don't seem to have any sexual desire. My husband feels that I'm rejecting him even though I explain that my body is changing. (it's only been a year since everything began). So, what I'm asking is, is the tamox responsible for my lack of sex drive or is it psychological or is it a combination of everything that's happened?
Answers —David Spiegel, Ph.D.: It is undoubtedly in part physiological. Many patients going through these treatments have artificially induced menopause. And because hormone levels are deliberately kept low, their sexual drive may in fact be reduced. In a way, though, this is the converse of the problem some other women were talking about, which was having trouble getting their husbands interested in them. It is good that he is interested in you and he is feeling some frustration if you are not up to it. It is a balance of listening to your body and doing what you feel like doing. It is also your reaction to the illness rather than the physiological change. You acknowledge your desire for your husband but you aren't pushed into something you don't want to do.

Editor's Note: Paxil (chemical name: paroxetine) is known to reduce the effectiveness of tamoxifen. If you are taking tamoxifen, talk to your doctor about alternatives to Paxil. For more information, please visit the Breastcancer.org Tamoxifen page.
Marisa Weiss, M.D., president and founder: All of the changes that you experience with breast cancer came on quite abruptly, but the solution for returning to a new sense of normal will happen much more gradually, and with a lot more work. So it will take a lot of patience, listening, and talking in a way with your husband that you may not have ever talked before.

On Wednesday, October 18, 2000, our Ask-the-Expert Online Conference was called Feelings about Breast Cancer. David Spiegel, Ph.D. and moderator Marisa Weiss, M.D. answered your questions about the emotional effects of breast cancer diagnosis and treatment.


The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Meet the Experts

David Spiegel, Ph.D.David Spiegel, Ph.D. is professor and associate chairman of psychiatry and behavioral sciences at Stanford University School of Medicine.

Marisa Weiss, M.D. is a radiation oncologist specializing in breast cancer and the founder, president, and guiding force behind Breastcancer.org.

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