Infertility certain after CMF?

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Question from Margaux: I'm having CMF chemotherapy treatments for 6 months -- that's a long time. That has to affect my fertility, right? I'm 40 but I still hold out hope for a pregnancy after treatment.
Answers - Leslie R. Schover, Ph.D. Unfortunately, after CMF (Cytoxan [chemical name: cyclophosphamide], methotrexate, and fluorouracil), about 90% of women over age 35 go into permanent menopause. So it is probably unlikely that you would be able to have your own biological child afterward. However, again, this is a situation where you could use a donor egg and there are certainly other ways to get a child.
Kutluk Oktay, M.D. If you have not started your treatments, you might undergo ovarian stimulation with aromatase inhibitors (letrozole [brand name: Femara]), which allows your estrogen levels to remain low while you freeze your eggs or embryos for future use, because getting pregnant with your own eggs after this treatment will be extremely unlikely.

The Ask-the-Expert Online Conference called Fertility and Pregnancy featured Kutluk Oktay, M.D. and Leslie Schover, Ph.D. answering your questions about breast cancer treatments that can affect your fertility, options for preserving your fertility, being treated for breast cancer while pregnant, and more.

Editor's Note: This conference took place in September 2008.

The materials presented in these conferences do not necessarily reflect the views of A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Copyright 2010. All rights reserved.

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