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Hormonal therapy for ER-negative, PR-positive?

Page last modified on: September 22, 2008
Question from Katie: Which hormonal therapies are effective with estrogen-negative, progesterone-positive breast cancer?
Answers —Sandra Schnall, M.D.: Most of them are as effective in either situation. I don't tend to recommend one hormonal therapy vs. another based on that alone.
Marisa Weiss, M.D., president and founder: Most oncologists consider a patient's cancer to be hormone-receptor-positive if either or both the estrogen and progesterone receptors are positive (meaning present).
Sandra Schnall, M.D.: We do quantify the percentage of them being present, so that less than 5% to 10% may not be strongly positive. If just the progesterone was 5% positive with the estrogen receptor being negative, it may not equate to a strong hormone response, but the treatment would be the same.

On Wednesday, April 21, 2004, our Ask-the-Expert Online Conference was called Hormonal Therapy Updates. Sandra Schnall, M.D. and Marisa Weiss, M.D. answered your questions about hormonal therapies and answered questions about which ones work best in different situations, how they might fit into your treatment sequence, how to deal with side effects, and more.

The materials presented in these conferences do not necessarily reflect the views of breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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Meet the Experts

Sandra F. Schnall, M.D.Sandra F. Schnall, M.D. is a medical oncologist/hematologist who practices at Bryn Mawr Hospital in the Thomas Jefferson University Health System outside of Philadelphia, Pennsylvania.

Marisa Weiss, M.D. is a radiation oncologist specializing in breast cancer and the founder, president, and guiding force behind Breastcancer.org.

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