Which medications cause chemo brain?

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Question from Terp: Which chemotherapy drugs are most likely to cause chemo brain?
Answers - Christina Meyers I would have to say we don't know enough. There are a number of agents that have been tested in animal models, and they all show something but there is really no basis for comparison.
George Sledge, M.D. The other issue is it's rare for us to treat a woman in the adjuvant setting with just one chemotherapy agent. It's common for a woman to receive several drugs at once.
Christina Meyers I'm not sure it even matters, because cancers come across various drugs so I look at patients with leukemia, prostate cancers, etc. — all different cancers with different drugs, and they all may have chemo brain symptoms.
George Sledge, M.D. High doses of drugs may give you more effects than a lower dose of the drugs, but again that doesn't tell us which drug. And a question we haven't looked at is whether regimens that are being administered for shorter periods of time are different from regimens for a longer time.

The Ask-the-Expert Online Conference called Managing Chemo Brain featured Christina Meyers, Ph.D., A.B.P.P. and George Sledge, M.D. answering your questions about how long chemo brain can last, what treatments can be helpful, and current research on cognitive effects of breast cancer treatment.

Editor's Note: This conference took place in October 2008.

The materials presented in these conferences do not necessarily reflect the views of Breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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