Stage IIIA and Operable IIIC

tumor greater than 5 cm with lymph nodes involved (IIIA) OR
tumor less than 5 cm and lymph nodes under the arm involved and clumped together (IIIA) OR
any size tumor with spread to more than 10 lymph nodes in or near the breast and/or lymph nodes near the neck or under the collarbone (operable IIIC)

total mastectomy followed by radiation

OR

lumpectomy plus radiation following chemotherapy to shrink a large single cancer

axillary lymph node removal by traditional approach

AND

possible radiation to supraclavicular and/or internal mammary lymph nodes

chemotherapy almost always recommended

hormonal therapy used for people with hormone-receptor-positive cancer

targeted therapy may be used for people with cancers that have certain characteristics (for example, cancers with too many HER2 protein receptors)

does not apply