Grapefruit interferes with targeted therapies?


Question from Joan: Grapefruit is said to inhibit one of the P450 enzymes involved in the metabolism of some chemotherapy drugs. Is it also potentially able to interfere with targeted drugs like Herceptin and Tykerb? If so, should grapefruit (and other citrus fruits?) be banned from the diets of patients on Herceptin and Tykerb?
Answers - Andrew D. Seidman, M.D. Very good question, and I honestly don't know if those specific drugs require this enzyme and how critical it is for the metabolism. It is certainly true that grapefruit juice as well as other food products can interfere with P450, but I'd have to refer this question to the drug manufacturer.

On Wednesday, July 19, 2006, our Ask-the-Expert Online Conference was called Targeted Therapies: What is Right for You?Andrew Seidman, M.D. and moderator Jennifer Armstrong, M.D. answered your questions about different kinds of targeted therapies and how they work.

The materials presented in these conferences do not necessarily reflect the views of Breastcancer.org. A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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