Grapefruit interferes with targeted therapies?

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Question from Joan: Grapefruit is said to inhibit one of the P450 enzymes involved in the metabolism of some chemotherapy drugs. Is it also potentially able to interfere with targeted drugs like Herceptin and Tykerb? If so, should grapefruit (and other citrus fruits?) be banned from the diets of patients on Herceptin and Tykerb?
Answers - Andrew D. Seidman, M.D. Very good question, and I honestly don't know if those specific drugs require this enzyme and how critical it is for the metabolism. It is certainly true that grapefruit juice as well as other food products can interfere with P450, but I'd have to refer this question to the drug manufacturer.

The Ask-the-Expert Online Conference called Targeted Therapies: What Is Right for You? featured Andrew Seidman, M.D. and moderator Jennifer Armstrong, M.D. answering your questions about different kinds of targeted therapies and how they work.

Editor's Note: This conference took place in July 2006.

The materials presented in these conferences do not necessarily reflect the views of A qualified healthcare professional should be consulted before using any therapeutic product or regimen discussed. All readers should verify all information and data before employing any therapies described here.

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