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Brand name: Jemperli

Chemical name: Dostarlimab-gxly

Class: PD-1 inhibitor

How it works: PD-1 is a checkpoint protein on T cells, immune system cells that attack foreign invaders in the body. PD-L1 is another checkpoint protein found on many healthy cells in the body. When PD-1 binds to PD-L1, it stops T cells from killing a cell. Some cancer cells have a lot of PD-L1 on their surface, which stops T cells from killing these cancer cells. An immune checkpoint inhibitor medicine such as Jemperli that stops PD-1 from binding to PD-L1 allows T cells to attack the cancer cells.

Uses: Jemperli is used:

  • to treat mismatch repair deficient (dMMR) advanced-stage breast cancer that has grown during or after treatment if no other treatment options are available
  • to treat dMMR advanced-stage endometrial cancer that has grown after treatment with platinum chemotherapy

How it’s given: Jemperli is given as an infusion.

Side effects:

Read more about Jemperli.

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