Brand name: Talzenna
Chemical name: Talazoparib
Class: PARP inhibitor. Lynparza is another PARP inhibitor
How it works: The poly ADP-ribose polymerase (PARP) enzyme fixes DNA damage in both healthy and cancer cells. Research has shown that a medicine like Talzenna, which interferes with (inhibits) the PARP enzyme, makes it harder for cancer cells with a BRCA1 or BRCA2 mutation to fix DNA damage. This makes it even harder for the cancer cells to survive. In other words, a PARP inhibitor makes some cancer cells less likely to survive their DNA damage.
Uses: Talzenna is used to treat locally advanced or metastatic HER2-negative breast cancer with an inherited BRCA1 or BRCA2 mutation.
How it’s given: Talzenna is a pill taken by mouth.
- anemia (low red blood cell counts)
- neutropenia (low white blood cell counts)
- thrombocytopenia (low platelet counts)
- hair loss
- decreased appetite
Read more about Talzenna.