Benzopyrones (brand name: Coumarin) were once used in countries outside the United States for the treatment of lymphedema. It was thought that these plant-based substances could help to break down the proteins in the excess lymph pooling in the body’s tissues. However, clinical trials have not confirmed their benefit and have shown that they can cause liver problems. Coumarin is not approved by the U.S. Food and Drug Administration and is not recommended for the treatment of lymphedema.
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