Antidepressants for Pain
What they are: Antidepressants are medications designed to correct abnormalities in the activity of brain chemicals known as neurotransmitters, which affect mood and behavior.
Examples include: Elavil (chemical name: amitryptiline), Pamelor (chemical name: nortriptyline), Norpramin (chemical name: desipramine), Cymbalta (chemical name: duloxetine)
What they're used for: Antidepressants are used to treat the pain of neuropathy (nerve damage), which can cause a sensation of tingling or burning. If your doctor prescribes an antidepressant for neuropathic pain, it does not mean you are depressed.
How they're taken: Antidepressants are taken by mouth.
Possible side effects include:
- dry mouth
- sleepiness
- constipation
- dizziness
- fainting
- blurred vision
- trouble passing urine
Antidepressants are not right for everyone who experiences pain, so be sure to talk with your doctor about your unique situation, symptoms, and needs.

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