Lynparza (chemical name: olaparib) is used to treat metastatic HER2-negative breast cancer with a BRCA1 or BRCA2 mutation that has previously been treated with chemotherapy.
Lynparza is a pill taken by mouth. The recommended starting dose of Lynparza is 300 mg taken twice per day, with or without food.
There are certain medicines, supplements, and foods you should not take or eat if you are taking Lynparza.
You should not take a type of medicine called a strong CYP3A inhibitor because it increases the effects of Lynparza. This class of medicines includes antifungal medicines such as Nizoral (chemical name: ketoconazole).
You should not take a type of medicine called a strong or moderate CYP3A inducer because it decreases the effects of Lynparza. This class of medicines includes Rifamate (chemical name: rifampin), an antibiotic used to treat tuberculosis.
You should not eat grapefruit or Seville oranges, or drink grapefruit juice or Seville orange juice, because they can increase the effects of Lynparza.
Pregnant women should not get targeted therapies such as Lynparza. The little research that has been done suggests that targeted therapies are not safe during pregnancy. Visit the Treatment for Breast Cancer During Pregnancy page for more information. You also should not breastfeed if you are taking Lynparza.
If your doctor prescribes Lynparza and you have problems getting it covered by insurance or have problems paying for the treatment, AstraZeneca, the company that makes Lynparza, may be able to help through the AZ&Me Prescription Savings Program. For more information, visit https://www.astrazeneca-us.com/medicines/Affordability.html or call 1-800-292-6363.
Also, the AstraZeneca Access 360 program connects patients to affordability programs and streamlines access and reimbursement for AstraZeneca medicines. Reimbursement counselors can help with prior authorization support, the reimbursement process, refer patients to assistance programs, and more. To learn more, call 1-844-275-2360 Monday through Friday, 8 a.m. to 8 p.m. EST or visit www.MyAccess360.com.