Lynparza is used to treat metastatic HER2-negative breast cancer with an inherited BRCA1 or BRCA2 mutation that has previously been treated chemotherapy.
Metastatic breast cancer is breast cancer that has spread to parts of the body away from the breast, such as the bones or liver.
You are substantially more likely to have a BRCA1 or BRCA2 mutation if:
- You have blood relatives (grandmothers, mother, sisters, aunts) on either your mother's or father's side of the family who had breast cancer diagnosed before age 50.
- There is both breast and ovarian cancer on the same side of the family or in a single individual.
- You have a relative(s) with triple-negative breast cancer.
- There are other cancers in your family in addition to breast, such as prostate, melanoma, pancreatic, stomach, uterine, thyroid, colon, and/or sarcoma.
- Women in your family have had cancer in both breasts.
- You are of Ashkenazi Jewish (Eastern European) heritage.
- You are African American and have been diagnosed with breast cancer at age 35 or younger.
- A man in your family has had breast cancer.
- There is a known abnormal breast cancer gene in your family.
A genetic test can determine whether you have a BRCA1 or BRCA2 mutation. A genetic test involves giving a blood or saliva sample that is analyzed to pick up any abnormalities in these genes.
For more information on genetic testing, including types of genetic tests and costs, visit the Breastcancer.org Genetic Testing pages.