Nerlynx Side Effects

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Women who are pregnant or nursing or are planning to get pregnant should not take Nerlynx. Nerlynx can cause embryo death and birth defects. It’s important that you don’t get pregnant while you’re taking Nerlynx; you must use effective birth control.

Severe diarrhea soon after starting Nerlynx is a very common side effect. In the ExteNET trial, about 40% of the women treated with Nerlynx had severe diarrhea as a side effect.

The FDA approval recommends that loperamide (brand names include Imodium, Kaopectate 1-D, and Pepto Diarrhea Control) be given with Nerlynx for the first 56 days of treatment and then as needed to help manage diarrhea.

Other common side effects of Nerlynx are:

In rare cases, Nerlynx may cause serious liver problems. Tell your doctor right away if you have any of the following signs of liver problems:

  • yellowing of the skin or the whites of the eyes
  • dark or brown urine
  • feeling very tired
  • loss of appetite
  • pain on the upper right side of the abdomen
  • bleeding or bruising more easily than normal

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