What to Expect When Taking Nerlynx

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Nerlynx is given within 2 years after you’ve had surgery and completed a chemotherapy regimen that includes Herceptin. Nerlynx is a pill taken by mouth.

The recommended dose of Nerlynx is 240 mg (6 tablets) once per day with food for 1 year.

If you take an antacid medicine, such as a proton pump inhibitor or an H2-receptor antagonist, you should wait 3 hours after taking the antacid to take Nerlynx. Prilosec, Prevacid, and Nexium are common proton pump inhibitors. Pepcid, Tagamet, and Zantac are common H2-receptor antagonists.

You should not take a type of medicine called a CYP3A inhibitor at the same time as Nerlynx because it increases the effects of Nerlynx. This class of medicines includes antifungal medicines such as Onmel (chemical name: itraconazole) and Biaxin (chemical name: clarithromycin), as well as antiretroviral drugs used to treat HIV such as Kaletra (chemical names: lopinavir and ritonavir).

You should not take a type of medicine called a CYP3A inducer at the same time as Nerlynx because it decreases the effects of Nerlynx. This class of medicines includes Rifamate (chemical name: rifampin), an antibiotic used to treat tuberculosis, and Carbatrol (chemical name: carbamazepine), which is used to control certain types of seizures in people with epilepsy.

You should not eat grapefruit or pomegranate or drink grapefruit juice or pomegranate juice, because they can increase the effects of Nerlynx.

If your doctor prescribes Nerlynx and you have problems paying for the medicine, the Nerlynx patient support program may be able to help you. Puma Biotechnology, the company that makes Nerlynx, has created a co-pay card for Nerlynx to help people pay for out-of-pocket costs associated with Nerlynx. To be eligible, you must have commercial insurance. For more information, visit the Nerlynx co-pay card webpage.


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