Vincristine: What to Expect, Side Effects, and More

Vincristine is typically used in combination with other chemotherapy drugs to treat several types of cancer, including leukemia and lymphoma. 

Brand names of vincristine include Oncovin*, Vincasar PFS, and Vincrex.

*Oncovin has been discontinued in the United States. 

Vincristine is a type of chemotherapy called a vinca alkaloid. The medicine works by interfering with cell division and triggering cell death.

Vinorelbine is another vinca alkaloid.

Vincristine is given intravenously. It’s usually given once a week.

You may get vincristine through a drip into your arm or hand — or, if necessary,  a central line. 

Be sure to tell your doctor what other medications you’re taking, including herbal supplements.

Like almost all breast cancer medicines, vincristine can cause side effects, some of them severe.

The most common side effects of vincristine are:

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  numbness and tingling in the hands and feet (neuropathy)

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  allergic reaction

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  nausea

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  vomiting

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  diarrhea

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  constipation

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  hair changes

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  fatigue

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  bone and joint pain

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  muscle and abdominal cramps

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  irregular periods — this can include temporary cessation (usually resume after medication is completed) or permanent cessation of menstrual periods depending on your age and other factors

More severe side effects may include:

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  heart problems

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  seizures

Vincristine is not recommended if you’re pregnant or nursing.

Members of our community discuss their experiences with vincristine in the community forum. Here are some of their comments. Remember, it's very important to talk to your doctor about any side effects you're having and ask about ways to manage them

“The vincristine and Taxotere both caused me a lot of tingling/numbness in my hands and feet during the chemo doses.” —Cincerely

Read more in our vincristine discussion forum.

The cost of vincristine may vary. The price you’ll pay depends on the drug manufacturer, your health insurance provider and plan, where you live, and the pharmacy you use. You may also be charged for the office visits required for vincristine infusions.

Note: Your insurance company may require you to get prior authorization before covering vincristine. 

Learn more about financial assistance and medicine cost-lowering tips.