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Faslodex

Faslodex (chemical name: fulvestrant) is an estrogen receptor downregulator (ERD) used alone or in combination with targeted therapy medicines to treat advanced-stage, hormone receptor-positive, HER2-negative breast cancer.
 

Faslodex (chemical name: fulvestrant) is an estrogen receptor downregulator (ERD) used:

  • as a first treatment for advanced-stage hormone receptor-positive HER2-negative breast cancer in postmenopausal women

  • to treat advanced-stage hormone receptor-positive HER2-negative breast cancer that has grown after hormonal therapy treatment in postmenopausal women

  • in combination with the targeted therapy Kisqali (chemical name: ribociclib) as a first treatment for advanced-stage hormone receptor-positive HER2-negative breast cancer in postmenopausal women; the combination of Faslodex and Kisqali also is used to treat advanced-stage hormone receptor-positive HER2-negative breast cancer that has grown after hormonal therapy treatment in postmenopausal women

  • in combination with either Ibrance (chemical name: palbociclib) or Verzenio (chemical name: abemaciclib) to treat advanced-stage hormone receptor-positive HER2-negative breast cancer that has grown after hormonal therapy treatment in pre- or postmenopausal women; both Ibrance and Verzenio are targeted therapies

Advanced-stage breast cancer is either locally advanced or metastatic. Locally advanced breast cancer is breast cancer that has spread to tissue near the breast, but not to parts of the body away from the breast. Metastatic breast cancer is breast cancer that has spread to parts of the body away from the breast, such as the bones or liver.

Faslodex will not work on hormone receptor-negative breast cancer.

Faslodex is available as a generic medicine.

 

How Faslodex works

Faslodex blocks the effects of estrogen on hormone receptor-positive breast cancer cells by sitting in the estrogen receptors on the cells. If Faslodex is in the receptor, estrogen can’t attach to the cancer cell and the cell doesn’t receive estrogen’s signals to grow and multiply.

Faslodex also changes the shape of the estrogen receptors so they don’t work as well.

 

Is Faslodex right for you?

If you’re a postmenopausal women diagnosed with advanced-stage, hormone receptor-positive, HER2-negative breast cancer, Faslodex may be used as a first treatment for the cancer. It also may be used as a second-line treatment if the breast cancer grows after treatment with a different hormonal therapy medicine.

Faslodex also is used in combination with three targeted therapy medicines to treat advanced-stage, hormone receptor-positive, HER2-negative breast cancer:

  • For postmenopausal women, Faslodex and Kisqali can be used as a first treatment or as a second-line treatment if the cancer grows after treatment with a different hormonal therapy medicine.

  • For pre- or post-menopausal women, Faslodex in combination with either Ibrance or
    Verzenio can be used as a second line treatment if the cancer grows after
    treatment with a different hormonal therapy.

You should not receive Faslodex if you are breastfeeding, pregnant, trying to get pregnant, or if there is any chance that you could be pregnant. Faslodex may cause damage to developing embryos. You should use an effective non-hormonal type of birth control while you are taking tamoxifen. Ask your doctor which type of non-hormonal birth control would be best for you. You should use the birth control for at least one year after your last dose of Faslodex.

 

What to expect during Faslodex treatment

Each Faslodex treatment is made up of two injections, one into each butt cheek. Each injection takes about one to two minutes. You receive the injections on days one, 15, and 29 of treatment, and then once per month after that.

If you have liver problems, you will likely get only one injection at each treatment.

 

Faslodex side effects

Like almost all breast cancer medicines, Faslodex can cause side effects, some of them severe.

The most common side effects of Faslodex are:

Faslodex also may cause serious side effects, including:

Bleeding problems: Faslodex can increase the risk of bleeding. If you take blood thinners or have a history of blood clots or bleeding disorders this risk may be much higher than average. Tell your doctor right away if you notice that a cut doesn’t stop bleeding.

 

Paying for Faslodex

If your doctor prescribes Faslodex and you have problems paying for it or getting it covered by insurance, the AstraZeneca Access 360 program may be able to help you.

Learn more about Paying for Your Care, including information on additional types of financial assistance and cost-lowering tips.

 
References

Faslodex prescribing information. AstraZeneca, USA> Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021344Orig1s039lbl.pdf

— Last updated on January 13, 2022, 4:09 PM

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