Larry Norton, M.D.


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Dr. Larry Norton is deputy physician-in-chief for breast cancer programs and the medical director of the Evelyn H. Lauder Breast Center at Memorial Sloan-Kettering Cancer Center (MSKCC). He is the first incumbent of the Norna S. Sarofim Chair in Clinical Oncology at MSKCC and recipient of the American Society of Clinical Oncology’s 2004 David A. Karnofsky Memorial Award.

He is also the principal investigator of a program project grant from the National Cancer Institute that is aimed at better understanding breast cancer in the laboratory and in bringing these advances into clinical practice. Dr. Norton's research concerns the basic biology of cancer, the mathematics of tumor causation and growth, and the development of approaches to better diagnosis, prevention, and drug treatment of the disease. He is involved in many research topics such as the molecular identification of genes that predispose people to cancer or otherwise cause cancer, the development of new drugs, monoclonal antibodies that target growth factor receptors, and vaccines.

Dr. Norton is most specifically identified with the development of an approach to therapy called "dose density," or "sequential dose density." This is a new and more effective way of using anticancer drugs, based on a mathematical model he developed with his colleagues, which maximizes the killing of cancer cells while minimizing toxicity.

Since its inception in 1993, Dr. Norton has served as chairman of the Medical Advisory Board of the Breast Cancer Research Foundation. He was formerly the chair of the Breast Committee of the National Cancer Institute's Cancer and Leukemia Group B. He was president of the American Society of Clinical Oncology from 2001 to 2002 and was a presidential appointee to the National Cancer Advisory Board of the National Cancer Institute from 1998 to 2004.

After receiving his M.D. from the College of Physicians and Surgeons, Columbia University, Dr. Norton trained in internal medicine at the Albert Einstein College of Medicine. He then served as a clinical associate and investigator at the NCI prior to joining the faculty of the Mount Sinai Medical Center in New York from 1977 to 1988. He is currently professor of medicine, Weill Medical College of Cornell University.

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