Lupron: What to Expect, Side Effects, and More

Lupron (chemical name: leuprolide) is an LHRH (luteinizing hormone-releasing hormone) agent hormonal therapy drug. Zoladex and Trelstar are also LHRHs.

See Lupron prescribing information. 

LHRHs shut down the ovaries and stop them from producing estrogen — so there is less estrogen to fuel the growth of hormone-receptor-positive breast cancer.

Because Lupron and other LHRHs stop the ovaries from working, they also can be used to help preserve fertility during chemotherapy and other treatments.

Lupron is given as an injection once a month for several months or every few months.

Typically, you can give yourself Lupron injections at home. 

Like almost all breast cancer medicines, Lupron can cause side effects, some of them severe.

The most common side effects of Lupron are:

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  hot flashes

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  mood swings

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  loss of libido

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  osteoporosis

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  breast tenderness

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  vaginal dryness, discharge, or itching

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  swelling of the hands, feet, ankles, or lower legs

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  pain, burning, or tingling in the hands or feet

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  weight changes

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  muscle or joint pain

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  depression

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  constipation

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  tiredness

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  acne

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  flu-like symptoms

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  memory problems

Members of our community discuss their experiences with Lupron in the community forum. Here are some of their comments. Remember, it's very important to talk to your doctor about any side effects you're having and ask about ways to manage them.

“The instant menopause side effects were tough. Every time I got a Lupron injection, side effects were sure to follow.” —pboi

“I have been on monthly Lupron shots for about a year and a half now. I also take tamoxifen. I admit I can't say I feel great on Lupron, but the side effects are manageable with few exceptions.” —chemicalworld

“I had my first Lupron injection on January 29th (4 weeks ago) and had no side effects and still had my period.” —LoveJoyPeace

Read more in our Lupron discussion forum.

The cost of Lupron may vary. The price you’ll pay depends on the drug manufacturer, your health insurance provider and plan, where you live, and the pharmacy you use.

Note: Your insurance company may require you to get prior authorization before covering Lupron. 

If you have trouble paying for Lupron, ask your care team about financial assistance programs that may be able to help.

Learn more about financial assistance and medicine cost-lowering tips.