Definitions of Recurrent and Metastatic Breast Cancer

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A recurrence or recurrent breast cancer is breast cancer that has come back after a period of time when it couldn't be detected. The cancer may come back in the same or opposite breast or chest wall.

A metastasis or metastatic breast cancer is breast cancer than has spread to another part of the body. Cancer cells can break away from the original tumor in the breast and travel to other parts of the body through the bloodstream or the lymphatic system, which is a large network of nodes and vessels that works to remove bacteria, viruses, and cellular waste products. (See the Breastcancer.org page on lymph nodes for a complete explanation of the lymphatic system.)

The metastatic tumor in a different part of the body is made up of cells from the breast cancer. So if breast cancer spreads to the bone, the metastatic tumor in the bone is made up of breast cancer cells, not bone cells.

Breast cancer can be "metastatic at diagnosis." This means that the cancer in the breast wasn't detected before it spread to another part of the body.

Metastatic breast cancer can be recurrent breast cancer if the original cancer has come back and spread to another part of the body. But most doctors use the term "locally recurrent" to describe breast cancer that has come back in the same breast/chest wall and "metastatic" to describe breast cancer that has spread to or come back in another part of the body.

Both recurrent and metastatic breast cancer are considered advanced-stage breast cancer.

Breast cancer can come back in the breast area or another part of the body months or years after the original diagnosis and treatment. Nearly 30% of women diagnosed with early-stage breast cancer will develop metastatic disease. In developing countries, most women diagnosed with breast cancer are diagnosed with advanced-stage or metastatic disease.



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