What to Expect When Taking Ibrance

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Ibrance can be prescribed with Femara (chemical name: letrozole), an aromatase inhibitor. Both medicines are pills taken by mouth.

You take the pills in a 28-day cycle:

  • for 21 days, you take the Ibrance and Femara pills at the same time each day, with food
  • then for 7 days, you take Femara only

You keep taking Ibrance with Femara as long as you are getting benefits from the medicines and aren’t having troubling side effects.

Ibrance also can be prescribed with Faslodex (chemical name: fulvestrant), an estrogen receptor downregulator. Faslodex is a liquid given as an injection into a muscle.

When taking Ibrance with Faslodex, it’s also taken on a 28-day cycle:

  • you take Ibrance for 21 days at the same time each day, with food, then you stop taking the Ibrance pills for 7 days
  • you receive an injection of Faslodex every two weeks for the first three injections and then one injection every 4 weeks

There are certain medicines, supplements, and foods you should not take or eat if you are taking Ibrance.

You should not take a type of medicine called a CYP3A inhibitor because it increases the effects of Ibrance. This class of medicines includes antifungal medicines such as Onmel (chemical name: itraconazole) and Biaxin (chemical name: clarithromycin), as well as antiretroviral drugs used to treat HIV such as Kaletra (chemical name: lopinavir and ritonavir).

You should not take a type of medicine called a CYP3A inducer because it decreases the effects of Ibrance. This class of medicines includes Rifamate (chemical name: rifampin), an antibiotic used to treat tuberculosis, and Carbatrol (chemical name: carbamazepine), which is used to control certain types of seizures in people with epilepsy.

You should not take St. John’s wort, an herb that is sometimes used to control depression and anxiety, because it can decrease the effects of Ibrance.

You should not eat grapefruit or pomegranate or drink grapefruit juice or pomegranate juice because they can increase the effects of Ibrance.

If your doctor prescribes Ibrance and you have any problems getting it covered by insurance, or you don’t have insurance, the Pfizer RxPathways Program may be able to help. To talk to a Pfizer RxPathways patient care coordinator, call 1-877-744-5675 or visit Pfizer RxPathways .

Pfizer also offers the Co-Pay One Savings Card for eligible people who have health insurance. The card offers eligible people out-of-pocket costs savings for Ibrance. For more information and to see if you are eligible, visit the Pfizer Co-Pay One Savings Program.  

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