Zometa Infusions: What to Expect, Side Effects, and More

Zometa (chemical name: zoledronic acid*) is used to reduce bone complications and bone pain caused by advanced-stage breast cancer that has spread to the bone. It's usually given with other chemotherapy medicines.

See Zometa prescribing information.

*Reclast is another brand name for zoledronic acid. It's used to treat osteoporosis.

Zometa is a  bisphosphonate. Bisphosphonates work by limiting the activity of certain bone cells, called osteoclasts. When breast cancer spreads (or metastasizes) to the bone, these osteoclasts cause bone weakening and destruction.

The destruction of bone may also increase blood calcium. Bisphosphonates also can help keep blood calcium levels normal.

Zometa is an intravenous drug, so you’ll need to visit your doctor’s office for your infusions. A Zometa drip takes at least 15 minutes — this is to prevent kidney damage.

If your doctor prescribes Zometa to prevent bone damage, you’ll likely have an infusion every 4-12 weeks.

You may need to take calcium and vitamin D supplements while you’re being treated with Zometa — talk to your doctor to find out more.

Like almost all breast cancer medicines, Zometa can cause side effects, some of them severe.

The most common side effects of Zometa are:

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  bone pain

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  nausea

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  vomiting

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  fever

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  fatigue

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  constipation

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  diarrhea

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  loss of appetite

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  teary eyes

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  heartburn

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  mouth sores

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  depression

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  vaginal discharge

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  hand-foot syndrome

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  hair changes

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  osteonecrosis of the jaw (loss of bone in the jaw)

Members of our community discuss their experiences with Zometa in the community forum. Here are some of their comments. Remember, it's very important to talk to your doctor about any side effects you're having and ask about ways to manage them.

“I've had three infusions of Zometa at six-month intervals and haven't had any side effects at all.” —reflect

“After my first Zometa infusion, I was so achy and sore the next morning that I could hardly get out of bed. I took two Extra Strength Tylenol and that helped. After subsequent Zometa infusions, I have been fine. Based on my experience, I wouldn't plan on going to work the next day after your first Zometa infusion, but traveling a few days later will probably be OK.” —bravepoint

“I had my first infusion on Thursday and was pretty much knocked flat on Friday. Flu-like symptoms are exactly how it feels: fever, headache, stiff, and sore. I’m better today, but not back to 100%. Next time, I’m planning on a Friday infusion so I won’t miss any work.” —lvc

Read more in our Zometa discussion forum. 

The cost of Zometa may vary. The price you’ll pay depends on your health insurance provider and plan, where you live, and the pharmacy you use. You may also be charged for the office visits required for Zometa infusions.

Note: Your insurance company may require you to get prior authorization before covering Zometa. 

If you have trouble paying for Zometa, ask your care team about financial assistance programs that may be able to help.

Learn more about financial assistance and medicine cost-lowering tips.